Mitochondrial transplant after ischemia reperfusion promotes cellular salvage and improves lung function during ex-vivo lung perfusion.

Caryn M CloerChristopher S GivensLakisha K BuieLauren K RochelleYi-Tzu LinSam PopaRandolph V M SheltonJames ZhanTyler R ZimmermanBria G JonesZion LesesneSarah S HoganThomas H Petersen

Published in: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation (2023)

These data provide direct evidence that mitochondrial transplant improves cellular health and lung function when administered during ex-vivo lung perfusion and suggest the mechanism of action may be through promotion of cellular autophagy. Data herein contribute new insights into the therapeutic potential of mitochondrial transplant to abate ischemia-reperfusion injury during lung transplant, and thus reduce graft rejection.

Keyphrases

lung function
oxidative stress
cystic fibrosis
chronic obstructive pulmonary disease
air pollution
ischemia reperfusion injury
electronic health record
healthcare
cell death
big data
mental health
signaling pathway
risk assessment
magnetic resonance imaging
health information
social media
artificial intelligence