Permanent tissue damage in multiple sclerosis lesions is associated with reduced pre-lesion myelin and axon volume fractions.
Ian J TaggeIlana R LeppertDumitru FetcoJennifer Sw CampbellDavid A RudkoRobert A BrownNikola StikovG Bruce PikePaul S GiacominiDouglas Lorne ArnoldSridar NarayananPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2022)
The present work demonstrated that pre-lesion abnormalities are associated with worse long-term lesion-level outcome.