Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain.
Anil K MalhotraChristoph U CorrellNabilah I ChowdhuryDaniel J MüllerPeter K GregersenAnnette T LeeArun K TiwariJohn M KaneW Wolfgang FleischhackerRene S KahnRoel A OphoffHerbert Y MeltzerTodd LenczJames L KennedyPublished in: Archives of general psychiatry (2012)
These data implicate MC4R in extreme SGA-induced weight gain and related metabolic disturbances. A priori identification of high-risk subjects could lead to alternative treatment strategies in this population.
Keyphrases
- weight gain
- drug induced
- liver injury
- copy number
- body mass index
- birth weight
- weight loss
- electronic health record
- genome wide
- adverse drug
- climate change
- big data
- dna methylation
- genome wide identification
- machine learning
- gene expression
- early onset
- binding protein
- artificial intelligence
- preterm birth
- endothelial cells