Comparison of Biomarker Assays for EGFR: Implications for Precision Medicine in Patients with Glioblastoma.

Andrew B LassmanLisa Roberts-RappIrina SokolovaMinghao SongEkaterina PestovaRupinder KularCarolyn MullenZheng ZhaXin LuErica GomezAnahita BhathenaDavid MaagPriya KumthekarHui Kong GanAndrew M ScottMaria GusevaKyle D HolenPeter J AnsellMartin J Van Den Bent

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Methods for assessing EGFR mRNA expression (RT-PCR, RNAseq) and copy number (WES), but not protein expression (IHC), can be used as surrogates for EGFR amplification (FISH) in GBM. Collectively, our results provide enhanced understanding of available screening options for patients, which may help guide EGFR-targeted therapeutic approaches.

Keyphrases

small cell lung cancer
epidermal growth factor receptor
copy number
tyrosine kinase
mitochondrial dna
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
high throughput
gene expression
cancer therapy
single cell