Biological and prognostic implications of biopsy upgrading for high-grade upper tract urothelial carcinoma at nephroureterectomy.
Satoshi KatayamaBenjamin PradereNico Christian GrossmannAaron M PotretzkeStephen A BoorjianAlireza GhoreifiSia DaneshmandHooman DjaladatJohn P SfakianosAndrea MariZine-Eddine KheneDavid D AndreaNozomi HayakawaAlberto BredaMatteo FontanaKazutoshi FujitaAlessandro AntonelliThomas van DoeverenChristina SteinbachKeiichiro MoriEkaterina LaukhtinaMorgan RouprêtVitaly MargulisPierre I KarakiewiczMotoo ArakiEva CompératYasutomo NasuShahrokh F ShariatPublished in: International journal of urology : official journal of the Japanese Urological Association (2022)
High tumor grade on URS biopsy is associated with features of biologically and clinically aggressive UTUC tumors. URS low-grade UTUC that becomes upgraded to high-grade might carry a better prognosis than high-grade UTUC on URS. Tumor specific factors are likely to be responsible for upgrading to high-grade on RNU.