Intrahepatic transcriptomics differentiate advanced fibrosis and clinical outcomes in adults with the Fontan circulation.

Katia Bravo-JaimesXiuju WuLeigh Christopher Reardon Gentian LluriJeannette P LinJeremy P MooreGlen Van ArsdellReshma BiniwaleMing-Sing SiBita V NainiRobert VenickSammy SaabChristopher L WrayReid PonderCarl RosenthalAlexandra KlomhausKristina I BöstromJamil A AboulhosnFady M Kaldas

Published in: medRxiv : the preprint server for health sciences (2023)

Patients with FALD and advanced liver fibrosis or the composite clinical outcome exhibit up-regulated genes including pathways related to inflammation, congestion, and angiogenesis. This adds further insight into FALD pathophysiology.

Keyphrases

liver fibrosis
oxidative stress
single cell
endothelial cells
genome wide
transcription factor
vascular endothelial growth factor
gene expression
dna methylation