Patient-derived organoid biobank identifies epigenetic dysregulation of intestinal epithelial MHC-I as a novel mechanism in severe Crohn's Disease.
Thomas W DennisonRachel D EdgarFelicity PayneKomal M NayakAlexander D B RossAurelie CenierClaire GlemasFederica GiacheroApril R FosterRebecca HarrisJudith KraiczyCamilla SalvestriniGeorgia StavrouFranco TorrenteKimberley BrookClaire TrayersRasa ElmentaiteGehad YoussefBálint TélDouglas James WintonNefeli Skoufou-PapoutsakiSam AdlerPhilip BuflerAline AzabdaftariAndreas JenkeNatasha GNatasha ThomasErasmo MieleAbdulrahman Al-MohammadGreta GuardaSubra KugathasanSuresh VenkateswaranMenna R ClatworthyTomas Castro-DopicoOndrej SuchanekCaterina StrisciuglioMarco GasparettoSeokjun LeeXingze XuErica BelloNamshik HanDaniel R ZerbinoSarah A TeichmannJosquin NysRobert HeuschkelFrancesca PerroneMatthias ZilbauerPublished in: Gut (2024)
Our study has identified epigenetically regulated intestinal epithelial MHC-I as a novel mechanism in CD pathogenesis.