Leishmania (Sauroleishmania) tarentolae versus pathogenic species: comparative evaluation of protease activity, glycoconjugates, resistance to complement and metabolome composition.
Filipe Fideles Duarte AndradeJéssica Gardone VitórioGisele André Baptista CanutoFernanda Freire Campos NunesIsabela Aurora RodriguesAna Paula Martins Morais AlmeidaFrederico Crepaldi NascimentoAdriana Oliveira CostaTamara da Silva VieiraAna Carolina Carvalho SilvaLeiliane Coelho AndréCélia Maria Ferreira GontijoCaroline JunqueiraJuliano Simões de ToledoAna Paula FernandesRodrigo Pedro SoaresPublished in: Memorias do Instituto Oswaldo Cruz (2024)
The non-pathogenic phenotype of L. tarentolae is associated with alterations in several biochemical and molecular features. This reinforces the need of comparative studies between pathogenic and non-pathogenic species to elucidate the molecular mechanisms of virulence during host-parasite interactions.