Targeting tumour-intrinsic N 7 -methylguanosine tRNA modification inhibits MDSC recruitment and improves anti-PD-1 efficacy.
Haining LiuXuezhen ZengXuxin RenYifan ZhangManling HuangLi TanZihao DaiJiaming LaiWenxuan XieZebin ChenSui PengLixia XuShuling ChenShunli ShenMing KuangShuibin LinPublished in: Gut (2022)
Our data uncover novel mechanisms underlying chemokine regulation and TIME shaping at the layer of messenger RNA translation level and provide new insights for development of efficient cancer immunotherapeutic strategies.