Weight loss after Roux-En-Y gastric bypass surgery reveals skeletal muscle DNA methylation changes.
Luis A GarciaSamantha E DayRichard L ColettaBaltazar CamposTonya R BenjaminEleanna De FilippisJames A MaduraLawrence J MandarinoLori R RoustDawn K ColettaPublished in: Clinical epigenetics (2021)
These results demonstrate that weight loss after RYGB alters the epigenome through DNA methylation. In particular, this study highlights ITGB3 as a novel gene that may contribute to the metabolic improvements observed post-surgery. Future additional studies are warranted to address the exact mechanism of ITGB3 in skeletal muscle.
Keyphrases
- roux en y gastric bypass
- weight loss
- dna methylation
- skeletal muscle
- gastric bypass
- genome wide
- bariatric surgery
- minimally invasive
- coronary artery bypass
- obese patients
- gene expression
- insulin resistance
- copy number
- glycemic control
- surgical site infection
- weight gain
- current status
- coronary artery disease
- metabolic syndrome
- body mass index
- genome wide identification