Identifying novel genes for amyotrophic lateral sclerosis by integrating human brain proteomes with genome-wide association data.

Xiao-Jing GuWei-Ming SuMeng DouZheng JiangQing-Qing DuanHan WangYan-Ling RenBei CaoYi WangYong-Ping Chen

Published in: Journal of neurology (2023)

SCFD1, CAMLG, and SARM1 exhibited robust associations and causality with ALS. The study findings provide novel clues for identifying potential therapeutic targets in ALS. Further studies are required to explore the mechanisms underlying the identified genes.

Keyphrases

amyotrophic lateral sclerosis
genome wide association
genome wide
bioinformatics analysis
electronic health record
big data
emergency department
deep learning
machine learning
climate change
risk assessment
adverse drug