SMARCB1 Gene Therapy Using a Novel Tumor-Targeted Nanomedicine Enhances Anti-Cancer Efficacy in a Mouse Model of Atypical Teratoid Rhabdoid Tumors.

Sang-Soo KimManish MogheAntonina RaitKathryn DonaldsonJoe B HarfordEsther H Chang

Published in: International journal of nanomedicine (2024)

Collectively, our data suggest that restoring SMARCB1 function via the scL-SMARCB1 nanocomplex may lead to therapeutic benefits in ATRT patients when combined with traditional chemoradiation therapies.

Keyphrases

gene therapy
mouse model
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
cancer therapy
peritoneal dialysis
rectal cancer
squamous cell carcinoma
electronic health record
patient reported outcomes
artificial intelligence
patient reported