Metabolic dysfunction-associated steatohepatitis exhibits sex differences in people with HIV.

Dana KablawiJovana MilicTyler ThomasThierry Fotsing TadjoFelice CinqueWesal ElgretliClaudia GioèBertrand LebouchéEmmanuel TsochatzisJemima FinkelSanjay BhaganiAntonio CascioGiovanni GuaraldiGiovanni MazzolaSahar SaeedGiada Sebastiani

Published in: HIV medicine (2024)

Despite women with HIV having a lower prevalence of MASH with fibrosis than men, they exhibit an acceleration in FAST score increase around the perimenopausal age. Future studies should target adequate consideration of sex differences in clinical investigation of metabolic dysfunction-associated steatotic liver disease to fill current gaps and implement precision medicine for people with HIV.

Keyphrases

antiretroviral therapy
hiv positive
hiv infected
hiv testing
human immunodeficiency virus
hepatitis c virus
hiv aids
men who have sex with men
oxidative stress
risk factors
postmenopausal women
liver fibrosis