Association of deficits in short-term learning and Aβ and hippocampal volume in cognitively normal adults.
Yen Ying LimJenalle E BakerLoren Richard BrunsAndrea MillsChristopher FowlerJurgen FrippStephanie R Rainey-SmithDavid AmesColin L MastersPaul MaruffPublished in: Neurology (2020)
These results suggest that in CN participants, Aβ+ is associated more strongly with a deficit in learning than any aspect of memory dysfunction. Slower rates of learning in Aβ+ CN participants were associated with hippocampal volume loss. Considered together, these data suggest that the primary cognitive consequence of Aβ+ is a failure to benefit from experience when exposed to novel stimuli, even over very short periods.