Treatment of Anal High-Grade Squamous Intraepithelial Lesions to Prevent Anal Cancer.
Joel M PalefskyJeannette Y LeeNaomi JayStephen E GoldstoneTeresa M DarraghHillary A DunlevyIsabella Rosa-CunhaAbigail AronsJulia C PuglieseDon VenaJoseph A SparanoTimothy J WilkinGary BucherElizabeth A StierMaribel Tirado GomezLisa FlowersLuis F BarrosoRonald T MitsuyasuShelly Y LensingJeffrey LoganDavid M AboulafiaJeffrey T SchoutenJuan de la OssaRebecca LevineJessica D KormanMichael HagenseeThomas M AtkinsonMark H EinsteinBernadette M CracchioloDorothy WileyGrant B EllsworthCristina BrickmanJ Michael Berry-Lawhornnull nullPublished in: The New England journal of medicine (2022)
Among participants with biopsy-proven anal HSIL, the risk of anal cancer was significantly lower with treatment for anal HSIL than with active monitoring. (Funded by the National Cancer Institute; ClinicalTrials.gov number, NCT02135419.).