Histone deacetylase 9 promoter hypomethylation associated with adipocyte dysfunction is a statin-related metabolic effect.

Amna KhamisRaphael BoutryMickaël CanouilSumi MathewStephane LobbensHutokshi CrouchToby AndrewAmar AbderrahmaniFilippo TamaniniPhillippe Froguel

Published in: Clinical epigenetics (2020)

We identified an epigenetic link between adipogenesis and adipose tissue insulin resistance in the context of T2D risk associated with statin use, which has important implications as HDAC9 and ABCG1 are considered potential therapeutic targets for obesity and metabolic diseases.

Keyphrases

histone deacetylase
adipose tissue
insulin resistance
high fat diet induced
dna methylation
cardiovascular disease
gene expression
coronary artery disease
metabolic syndrome
high fat diet
type diabetes
skeletal muscle
transcription factor
oxidative stress
weight gain
body mass index