Clonidine inhibits anti-non-Gal IgM xenoantibody elicited in multiple pig-to-primate models.
John M StewartAlice F TarantalWayne J HawthorneEvelyn J SalvarisPhilip J O'ConnellMark B NottleAnthony J F d'ApicePeter J CowanMary Kearns-JonkerPublished in: Xenotransplantation (2015)
Clinically relevant small molecule drugs with known safety profiles can inhibit xenoantibody elicited against non-Gal antigens in diverse experimental xenotransplantation settings. These molecules are ready to be tested in large animal models. However, it will first be necessary to optimize the timing and dosing required to inhibit xenoantibodies in vivo.