The GH/IGF-1 Axis Is Associated With Intrahepatic Lipid Content and Hepatocellular Damage in Overweight/Obesity.

Laura E DichtelKathleen E CoreyMelanie S HainesMark L ChicoteAllison KimballCaitlin CollingTracey G SimonMichelle T LongJad HusseiniMiriam A BredellaKaren K Miller

Published in: The Journal of clinical endocrinology and metabolism (2022)

Individuals with NAFLD have lower peak-stimulated GH levels but similar IGF-1 levels as compared to controls. Higher peak-stimulated GH levels are associated with lower IHL and less hepatocellular damage. Higher IGF-1 levels are associated with more favorable fibrosis risk scores. These data implicate GH and IGF-1 as potential disease modifiers in the development and progression of NAFLD.

Keyphrases

growth hormone
weight loss
binding protein
oxidative stress
type diabetes
insulin resistance
physical activity
weight gain
adipose tissue
machine learning
big data
artificial intelligence
human health
data analysis