CD19-CAR T-cell therapy induces deep tissue depletion of B cells.
Carlo TurMarkus EcksteinJoachim VeldenSimon RauberChristina BergmannJanina AuthLaura BucciGiulia CorteMelanie HagenAndreas WirschingRicardo Grieshaber-BouyerPetra ReisNicolai KittanJochen WackerAleix Rius RigauAndreas RammingMaria Antonietta D'AgostinoArndt HartmannFabian MüllerAndreas MackensenAline BozecLarissa Valor-MéndezMaria Gabriella RaimondoPublished in: Annals of the rheumatic diseases (2024)
This study demonstrates complete B-cell depletion in secondary lymphoid tissues of patients with AIDs following CD19-CAR T-cell therapy combined with standard lymphodepleting therapy.