Genetic interplay between transcription factor Pou4f1/Brn3a and neurotrophin receptor Ret in retinal ganglion cell type specification.

Vladimir Vladimirovich MuzykaTudor Constantin Badea

Published in: Neural development (2021)

Based on these observations, we propose that Brn3a and Ret converge onto developmental pathways that control RGC type specification, potentially through a competitive mechanism requiring signaling from the surrounding tissue.

Keyphrases

transcription factor
cell fate
genome wide
dna binding
copy number
gene expression
dna methylation
binding protein