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MFN2 Prevents Neointimal Hyperplasia in Vein Grafts via Destabilizing PFK1.
Yuanjun Tang
Yiting Jia
Linwei Fan
Han Liu
Yuan Zhou
Miao Wang
Yuefeng Liu
Juanjuan Zhu
Wei Pang
Jing Zhou
Published in:
Circulation research (2022)
MFN2 is a mechanoresponsive protein that interacts with PFK1 to mediate PFK1 degradation and therefore suppresses glycolysis in VSMCs.
Keyphrases
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vascular smooth muscle cells
binding protein
signaling pathway
smooth muscle
protein protein
mouse model
small molecule