Associations between plasma kynurenines and cognitive function in individuals with normal glucose metabolism, prediabetes and type 2 diabetes: the Maastricht Study.
Lieke BakkerInez H G B RamakersMartin P J van BoxtelMiranda T SchramCoen D A StehouwerCarla J H van der KallenPieter C DagnelieMarleen M J van GreevenbroekAnke WesseliusØivind MidttunPer M UelandFrans R J VerheySimone J P M EussenSebastiaan KöhlerPublished in: Diabetologia (2021)
Several kynurenines were cross-sectionally associated with lower odds of cognitive impairment and better cognitive functioning in type 2 diabetes, while less widespread associations were seen in prediabetes. Low levels of kynurenines might be involved in the pathway of type 2 diabetes and cognitive decline but this needs further studies.