TIM3+ cells in gastric cancer: clinical correlates and association with immune context.

Ke ChenYun GuYifan CaoHanji FangKunpeng LvXin LiuXudong HeJieti WangChao LinHao LiuHeng ZhangHongyong HeJiejie XuHe LiRuochen Li

Published in: British journal of cancer (2021)

The abundance of tumour-infiltrating TIM3+ cells could identify an immunoevasive subtype gastric cancer with CD8+ T cell dysfunction, suggesting that TIM3 might serve as a promising target for immunotherapy in gastric cancer.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
signaling pathway