Therapeutic efficacy of the novel selective RNA polymerase I inhibitor CX-5461 on pulmonary arterial hypertension and associated vascular remodelling.
Xia XuHua FengChaochao DaiWeida LuJun ZhangXiaosun GuoQihui YinJianli WangXiaopei CuiFan JiangPublished in: British journal of pharmacology (2021)
Our results suggest that pharmacological inhibition of Pol I may be a novel therapeutic strategy to treat otherwise drug-resistant PAH.