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Exploration of Berberine Against Ulcerative Colitis via TLR4/NF-κB/HIF-1α Pathway by Bioinformatics and Experimental Validation.

Jilei LiWenchao DanChenchen ZhangNian LiuYichong WangJixiang LiuShengsheng Zhang
Published in: Drug design, development and therapy (2024)
Through network pharmacology analysis and experimental substantiation, this study confirmed that berberine enhances UC treatment outcomes by inhibiting the TLR4/NF-κB/HIF-1α axis, thereby mitigating inflammatory reactions and improving colonic pathology.
Keyphrases
  • ulcerative colitis
  • signaling pathway
  • nuclear factor
  • toll like receptor
  • inflammatory response
  • lps induced
  • oxidative stress
  • immune response
  • pi k akt
  • endothelial cells
  • cell proliferation