Valosin-containing protein (VCP/p97) is prognostically unfavorable in pediatric AML, and negatively correlates with unfolded protein response proteins IRE1 and GRP78: A report from the Children's Oncology Group.

Fieke W HoffYihua QiuBrandon D BrownRobert B GerbingAmanda R LeontiRhonda E RiesAlan S GamisRichard AplencEdward Anders KolbTodd A AlonzoSoheil MeshinchiGaye N JenkinsTerzah M HortonSteven M Kornblau

Published in: Proteomics. Clinical applications (2023)

Our findings suggest the potential of the protein VCP as biomarker in prognostication prediction in pediatric AML.

Keyphrases

acute myeloid leukemia
endoplasmic reticulum stress
protein protein
amino acid
binding protein
young adults
small molecule
allogeneic hematopoietic stem cell transplantation
climate change
risk assessment
acute lymphoblastic leukemia