Haneummycin, a new 22-membered macrolide lactam antibiotic, produced by marine-derived Streptomyces sp. KM77-8.
Moeka UemuraKeisuke KobayashiNoriko SatoKenichiro NagaiReiko SekiMichiya KamioTakashi FukudaTaishi TsubouchiHiroshi TomodaTaichi OhshiroTakeshi KobayashiTakeshi TeraharaPublished in: The Journal of antibiotics (2023)
A new antibiotic named haneummycin (1) was isolated from a culture broth of marine-derived Streptomyces sp. KM77-8 by solvent extraction and HPLC using a C4 column. The structure of 1 was elucidated including relative stereochemistry as a new 22-membered macrolide lactam associated with a cyclopentanone and three sugars by various spectroscopic analyses, such as MS and NMR. Compound 1 displayed significant antibacterial activities against Gram-positive bacteria including vancomycin-resistant Enterococcus faecium (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) with both MIC values of 8.0 µg ml -1 .
Keyphrases
- methicillin resistant staphylococcus aureus
- gram negative
- ms ms
- staphylococcus aureus
- mass spectrometry
- multidrug resistant
- multiple sclerosis
- high resolution
- solid phase extraction
- magnetic resonance
- simultaneous determination
- liquid chromatography
- biofilm formation
- molecular docking
- high performance liquid chromatography
- tandem mass spectrometry
- ionic liquid
- pseudomonas aeruginosa
- escherichia coli
- solid state