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A Timeless Tale: G4 structure recognition by the fork protection complex triggers unwinding by DDX11 helicase.

Catherine H Freudenreich
Published in: The EMBO journal (2020)
How the replisome senses and deals with DNA secondary structures has been a mystery. A new study from the Sale and Pellegrini laboratories finds that the Timeless protein has a G-quadruplex binding domain that works together with the DDX11 helicase to facilitate replication of G4 DNA structures.
Keyphrases
  • circulating tumor
  • cell free
  • single molecule
  • high resolution
  • binding protein
  • nucleic acid
  • mass spectrometry
  • amino acid