A mouse model of binge alcohol consumption and Burkholderia infection.

Victor JimenezRyan MorenoErik W Settles Bart J Currie Paul S Keim Fernando P Monroy

Published in: PloS one (2018)

Our results indicate that a single binge alcohol dose suppressed innate immune functions and increased the ability of less virulent Burkholderia strains to disseminate through increased barrier permeability and intracellular invasion of non-phagocytic cells.

Keyphrases

alcohol consumption
innate immune
mouse model
induced apoptosis
cell cycle arrest
escherichia coli
endothelial cells
endoplasmic reticulum stress
signaling pathway
reactive oxygen species