A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity.

Eleftherios KostarasTeresa KasererGlorianne LazaroSara Farrah HeussAasia HussainPedro CasadoAngela HayesCihangir YandimNicolaos PalaskasYi YuBrian SchwartzFlorence RaynaudYuen-Li ChungPedro R CutillasIgor Vivanco

Published in: British journal of cancer (2020)

These findings illustrate the utility of individual AKT inhibitors, both as drugs and as chemical probes, and the benefit of AKT inhibitor pharmacological diversity in providing a repertoire of context-specific therapeutic options.

Keyphrases

signaling pathway
cell proliferation
small molecule
single molecule
fluorescence imaging