Association between polymorphisms in microRNA seed region and warfarin stable dose.

Maryam HosseindokhtHamed ZareRasoul SalehiLeyla PourgholiShayan ZiaeeMohammadali BoroumandMohammad Jafar Sharifi

Published in: Postgraduate medical journal (2020)

rs2910164 C/G in the seed region of miR-146a is associated with warfarin maintenance dose, likely by disrupting interaction between miR-146a and ATP-binding cassette subfamily B member 1 gene, ABCB1. Therefore, this polymorphism may possibly be a potential factor for assessment of warfarin dose requirements.

Keyphrases

atrial fibrillation
cell proliferation
direct oral anticoagulants
venous thromboembolism
long non coding rna
long noncoding rna
oral anticoagulants
genome wide
copy number
genome wide identification
gene expression
risk assessment
dna methylation
transcription factor