Determinants of early change in serum creatinine after initiation of dolutegravir-based antiretroviral therapy in South Africa.

Rephaim Mpofu Aida Nakayiwa Kawuma Roeland E Wasmann Godspower Akpomiemie Nomathemba C Chandiwana Simiso Mandisa Sokhela Michelle A Moorhouse Willem Daniel Francois Venter Paolo Denti Lubbe Wiesner Frank A Post David W Haas Gary Maartens Phumla Z Sinxadi

Published in: British journal of clinical pharmacology (2024)

Multiple clinical and pharmacokinetic factors were associated with early change in serum creatinine in individuals initiating dolutegravir-based ART. UGT1A1 polymorphisms may play a role, but further research on genetic determinants is needed.

Keyphrases

antiretroviral therapy
hiv positive
hiv infected
hiv infected patients
human immunodeficiency virus
south africa
hiv aids
uric acid
genome wide
gene expression
copy number
hepatitis c virus