Using Pharmacokinetic Modeling and Electronic Health Record Data to Predict Clinical and Safety Outcomes after Methylprednisolone Exposure during Cardiopulmonary Bypass in Neonates.

Henry P FooteHuali WuStephen J BalevicElizabeth J ThompsonKevin D HillEric M GrahamChristoph P HornikKaran R Kumar

Published in: Congenital heart disease (2023)

Pro-inflammatory IL-6, but not MP exposure, was associated with post-operative organ dysfunction, suggesting current MP dosing may not adequately suppress IL-6 or increase IL-10 to impact clinical outcomes. Prospective study will be required to define the optimal exposure-efficacy and exposure-safety profiles in these infants.

Keyphrases

electronic health record
clinical decision support
high dose
machine learning
preterm infants
low birth weight
deep learning