Matrix effects of the hydroethanolic extract and the butanol fraction of calyces from Physalis peruviana L. on the biopharmaceutics classification of rutin.
Gina Paola Domínguez MoréClarissa FeltrinPaula Freire BrambilaMaría Isabel CardonaSandra Milena EcheverryCláudia Maria Oliveira SimõesDiana Marcela AragónPublished in: The Journal of pharmacy and pharmacology (2020)
According to these results, rutin could be classified as BCS classes III (high solubility/low permeability) and IV (low solubility/low permeability), depending on the plant matrix. Further work needs to be done in order to establish how apply the BCS for research and development of new botanical drugs or for bioequivalence purposes.