Role of sex and high-fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer's disease.

Lisa S RobisonOlivia J GannonMelissa A ThomasAbigail E SalineroCharly Abi-GhanemYannick PoitelonSophie BelinKristen L Zuloaga

Published in: Journal of neuroinflammation (2020)

These findings provide further evidence for the roles of hypothalamic and metabolic dysfunction in AD, which in the 3xTg-AD mouse model appears to be dependent on both sex and diet.

Keyphrases

high fat diet
mouse model
insulin resistance
adipose tissue
physical activity
cognitive decline
oxidative stress
type diabetes
skeletal muscle