Combination of atorvastatin and gemfibrozil plus physical activity: an animal model of statin/fibrate-induced myopathy.

Mohsen ZabihiFatemeh AskarianSeyedhossein HekmatimoghaddamMohammad Sajjad ZabihiFirouzeh Vahidi

Published in: Somatosensory & motor research (2020)

The results showed a significantly (p < 0.05) decreased swimming tolerance time and elevated enzyme levels in rats receiving atorvastatin (ATV) and gemfibrozil (GMF) plus exercise compared with those rats in other groups. This animal model can be used to evaluate the effects of medication on reduction of statin/fibrate-induced myopathy.

Keyphrases

physical activity
high glucose
diabetic rats
cardiovascular disease
coronary artery disease
late onset
healthcare
drug induced
body mass index
high intensity
type diabetes
emergency department
muscular dystrophy
body composition
sleep quality
myasthenia gravis