[Which immunoglobulin heavy chains for which immunostimulatory antibodies?]

Immunostimulatory antibodies in cancer rely on different mechanisms of action, simple blocking of immune checkpoints, depletion of tumour-infiltrating regulatory T cells, agonistic action on lymphocyte activatory receptors, etc. Choosing the relevant heavy chain isotype or the adequate engineering variant of this heavy chain is critical for the therapeutic efficacy, since the aforementioned properties sometimes bring into play the Fc region and the hinge region. This short review tries to learn the lessons from the clinical experience.