Tartrolon D induces immunogenic cell death in melanoma.
Thaís Lima de BritoEvelline Araújo EdsonKatharine Gurgel Dias FlorêncioJoão Agostinho Machado-NetoAnali Del Milagro Bernabe GarniqueJoão Paulo Mesquita LuizFernando de Queiroz CunhaJosé Carlos Alves-FilhoMargo HaygoodDiego Veras WilkePublished in: Chemico-biological interactions (2024)
In spite of recent advances provided by target therapy and immunotherapy, advanced metastatic melanoma is incurable for more than half of patients. ICD inducers yield better and long-lasting responses to anticancer treatment. Our findings shed light on an anticancer candidate of marine origin that induces ICD in melanoma.