Cerebrospinal fluid levels of the neurotrophic factor neuroleukin are increased in early Alzheimer's disease, but not in cerebral amyloid angiopathy.
Anna M De KortH Bea KuiperijDaniel AlcoleaIris KerstenAlexandra A M VersleijenSteven M GreenbergErik StoopsFloris H B M SchreuderCatharina J M KlijnAlberto LleóJurgen A H R ClaassenMarcel M VerbeekPublished in: Alzheimer's research & therapy (2021)
We found that CSF NLK levels are elevated in aMCI and AD patients compared to controls, but are not increased in CAA patients. CSF NLK levels may be related to an increased neuroinflammatory state in early stages of AD, given its association with YKL-40.