Multi-Tiered Assessment of Gene Expression Provides Evidence for Mechanisms That Underlie Risk for Type 2 Diabetes.

Kesava AsamKimberly A Lewis Kord M KoberXingyue GongAlka M KanayaBradley E AouizeratElena Flowers

Published in: Diabetes, metabolic syndrome and obesity : targets and therapy (2023)

We validated prior studies that showed pathways related to metabolism, inflammation/immunity, and endocrine/hormone function are related to risk for T2D. We identified evidence for new potential mechanisms that include protein misfolding. Additional studies are needed to determine whether these are potential therapeutic targets to decrease risk for T2D.

Keyphrases

gene expression
type diabetes
insulin resistance
case control
metabolic syndrome
risk assessment
binding protein
human health