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Acute Adenoviral Infection Elicits an Arrhythmogenic Substrate Prior to Myocarditis.

Rachel L PadgetMichael J ZeitzGrace A BlairXiaobo WuMichael D NorthMira T TanenbaumKari E StanleyChelsea M PhillipsD Ryan KingSamy LamouilleRobert G GourdieGregory S HoekerSharon A SwangerSteven PoelzingJames W Smyth
Published in: Circulation research (2024)
Together, these findings demonstrate that adenoviral infection creates an arrhythmogenic substrate through direct targeting of gap junction and ion channel function in the heart. Such alterations are known to precipitate arrhythmias and likely contribute to sudden cardiac death in acutely infected patients.
Keyphrases
  • liver failure
  • heart failure
  • atrial fibrillation
  • respiratory failure
  • cancer therapy
  • amino acid
  • drug induced
  • intensive care unit
  • congenital heart disease
  • structural basis
  • aortic dissection
  • drug delivery