LncRNA TRERNA1 facilitates hepatocellular carcinoma metastasis by dimethylating H3K9 in the CDH1 promoter region via the recruitment of the EHMT2/SNAI1 complex.

Wei SongYuejun GuSen LuHuazhang WuZhenxing ChengJiaojiao HuYanyan QianYing ZhengHong Fan

Published in: Cell proliferation (2019)

For the first time, the current study reveals that TRERNA1 promotes cell metastasis and the invasion of HCC via the recruitment of EHMT2 and/or the EHMT2/SNAI1 complex to suppress CDH1. These data identify a novel mechanism that regulates TRERNA1 in metastatic HCC and provides a potential targeted therapy for HCC patients.

Keyphrases

end stage renal disease
chronic kidney disease
small cell lung cancer
squamous cell carcinoma
gene expression
single cell
cell therapy
long non coding rna
transcription factor
stem cells
big data
cancer therapy
patient reported outcomes
human health
long noncoding rna