Safety evaluation of oral calcitonin-gene-related peptide receptor antagonists in patients with acute migraine: a systematic review and meta-analysis.

Seoyeon LeeChristine E Staatz Nayoung Han In-Hwan Baek

Published in: European journal of clinical pharmacology (2022)

Despite oral CGRP receptor antagonists posing a significantly higher risk of AEs when compared to placebo, CGRP receptor antagonists have a favorable safety profile compared to triptans. Our findings inform strategies to enhance safety and tolerability in the treatment of acute migraine.

Keyphrases

liver failure
clinical trial
open label
double blind
genome wide
intensive care unit
gene expression
drug induced
placebo controlled
phase iii
acute respiratory distress syndrome
aortic dissection