Neurodegenerative changes in early- and late-onset cognitive impairment with and without brain amyloidosis.
Eddie C StageDiana SvaldiMeredith PhillipsVictor Hugo CanelaTugce DuranNaira GoukasianShannon L RisacherAndrew J SaykinLiana G Apostolovanull nullPublished in: Alzheimer's research & therapy (2020)
LOnonAD subjects show a fronto-temporal neurodegenerative pattern in the absence of tau binding, which may represent underlying hippocampal sclerosis with TDP-43, also known as limbic-predominant age-related TDP-43 encephalopathy (LATE). The hypometabolic pattern observed in EOnonADDEM seems similar to the one observed in EOADMCI. Further investigation into the underlying etiology of EOnonAD is warranted.