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In vitro changes in the proportion of protein-unbound-free propofol induced by valproate.

Minako Ishii-MaruhamaHitoshi HiguchiMai NakanouYuka Honda-WakasugiAkiko Yabuki-KawaseShigeru MaedaTakuya Miyawaki
Published in: Journal of anesthesia (2018)
VPA might increase the proportion of protein-unbound-free propofol in human serum via displacement reactions.
Keyphrases
  • protein protein
  • amino acid
  • binding protein
  • small molecule