Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle.

Christopher A BishopTina MachateThorsten HenningJanin HenkelGerhard PüschelDaniela WeberTilman GruneSusanne KlausKarolin Weitkunat

Published in: Nutrition & diabetes (2022)

These data demonstrate the detrimental role of valine in an HF context and elucidate additional targetable pathways in the etiology of BCAA-induced obesity and insulin resistance.

Keyphrases

insulin resistance
skeletal muscle
high glucose
metabolic syndrome
type diabetes
diabetic rats
adipose tissue
high fat diet induced
high fat diet
polycystic ovary syndrome
weight loss
endothelial cells
weight gain
body mass index
big data
machine learning
oxidative stress
glycemic control