Implicit action primes and inaction primes can directly affect effort in some circumstances. The present research examined if people high in trait self-focused attention were more strongly affected by action and inaction primes. Past work has found that self-focus makes people more likely to encode implicit primes as self-relevant, thus increasing the effects of primes. As a result, we expected that people high in trait self-focus would be more strongly affected when primed with action and inaction concepts. A group of young adults completed a self-paced parity task in which most trials primed words related to action or inaction. Effort was measured as baseline-to-task change in the cardiac pre-ejection period (PEP), a measure of sympathetic autonomic influence on the heart. Trait self-focus significantly interacted with the priming manipulation. People high in self-focus were more sensitive to the action primes, shown in greater PEP reactivity, but not to the inaction primes. The findings extend the growing literature on how priming influences effort and support models of how self-focused attention shapes motivational processes.