Effects of cohort, genotype, variant, and maternal β-blocker treatment on foetal heart rate predictors of inherited long QT syndrome.

Alexander M Kaizer Annika Winbo Sally-Ann B Clur Susan P Etheridge Michael J Ackerman Hitoshi Horigome Ulrike Herberg Federica Dagradi Carla Spazzolini Stacy A S Killen Annette Wacker-Gussmann Arthur A M WildeElena SinkovskayaAlfred AbuhamadMargherita TorchioChai-Ann Ng Annika Rydberg Peter J Schwartz Bettina F Cuneo

Published in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2023)

Genotype, LQT1 variant, and maternal β-blocker therapy affect FHR. A predictive threshold of FHR/GA significantly improves the accuracy, sensitivity, and specificity for LQT1 and LQT2, above the infant's a priori 50% probability. We speculate this model may be useful in screening for LQTS in perinatal subjects without a known LQTS family history.

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