Toll-like Receptor 4 Differentially Modulates Cardiac Function in Response to Chronic Exposure to High-Fat Diet and Pressure Overload.
Liping TianMohammad JarrahHussein HerzYi ChuYing XuYiqun TangJinxiang YuanMohamad MokademPublished in: Nutrients (2023)
TLR4 deficiency provided protection against HFD-induced myocardial inflammation but impaired hemodynamic cardiac function under pressure overload conditions. These findings highlight the crucial role of TLR4 and its downstream signaling pathway in maintaining cardiac output during physiologic cardiac hypertrophy in response to pressure overload.
Keyphrases
- toll like receptor
- high fat diet
- inflammatory response
- nuclear factor
- insulin resistance
- adipose tissue
- immune response
- signaling pathway
- oxidative stress
- diabetic rats
- epithelial mesenchymal transition
- replacement therapy
- metabolic syndrome
- atrial fibrillation
- induced apoptosis
- endoplasmic reticulum stress
- stress induced