GDF11 inhibits adipogenesis and improves mature adipocytes metabolic function via WNT/β-catenin and ALK5/SMAD2/3 pathways.
Jan FrohlichKristina KovacovicovaMarco RaffaeleTereza VirglovaEliska CizkovaJan KuceraJulie Bienertova-VaskuMartin WabitschMarion PeyrouFrancesca BonominiRita RezzaniGeorge N ChaldakovAnton B TonchevMichelino Di RosaNicolas BlavetVaclav HejretManlio VinciguerraPublished in: Cell proliferation (2022)
We show evidence that link GDF11 to adipogenic differentiation, glucose, and insulin homeostasis, which are pointing towards potential beneficial effects of GDF11-based "anti-obesity" therapy.
Keyphrases
- high fat diet induced
- type diabetes
- epithelial mesenchymal transition
- cell proliferation
- insulin resistance
- metabolic syndrome
- weight loss
- adipose tissue
- stem cells
- transforming growth factor
- weight gain
- glycemic control
- advanced non small cell lung cancer
- blood glucose
- risk assessment
- signaling pathway
- skeletal muscle
- mesenchymal stem cells
- body mass index
- human health
- climate change